Journal Articles


Yin, M., Pu, T., Wang, L., Marshall, C., Wu, T., & Xiao, M. (2018). Astroglial water channel aquaporin 4-mediated glymphatic clearance function: A determined factor for time-sensitive treatment of aerobic exercise in patients with Alzheimer’s disease. Medical Hypotheses, 119, 18-21. DOI: 10.1016/j.mehy.2018.07.016

Wang, L., Zhang, Y., Zhao, Y., Marshall, C., Wu, T., & Xiao, M. (2018). Deep cervical lymph node ligation aggravates AD‐like pathology of APP/PS1 mice. Brain Pathology. DOI: 10.1111/bpa.12656

Tuttle, N. & Hazle, C. (2018). Spinal PA movements behave ‘as if’ there are limitations of local segmental mobility and are large enough to be perceivable by manual palpation: A synthesis of the literature. Musculoskeletal Science and Practice, 36, 25-31. DOI: 10.1016/j.msksp.2018.04.005

Gao, J., Chen, Y., Su, D., Marshall, C., & Xiao, M. (2018). Depressive- and anxiety-like phenotypes in young adult APPSwe/PS1dE9 transgenic mice with insensitivity to chronic mild stress. Behavioural Brain Research, 353, 114-123. DOI: 10.1016/j.bbr.2018.07.007

Cardarelli, R., Horsley, M., Ray, L., Maggard, N., Schilling, J., Weatherford, S., Feltner, F., & Gilliam, K. (2018). Reducing 30-day readmission rates in a high-risk population using a lay-health worker model in Appalachia Kentucky. Health Education Research, 33(1), 73-80. DOI: 10.1093/her/cyx064

Snell-Rood, C., Feltner, F., & Schoenberg, N. (2018). What role can community health workers play in connecting rural women with depression to the “de facto” mental health care system? Community Mental Health Journal. DOI: 10.1007/s10597-017-0221-9


Snell-Rood, C., Hauenstein, E., Leukefeld, C., Feltner, F., Marcum, A., & Schoenberg, N. (2017). Mental health treatment seeking patterns and preferences of Appalachian women with depressionAmerican Journal of Orthopsychiatry, 87(3), 233-241. DOI: 10.1037/ort0000193

Feltner, F., Thompson, S., Baker, W., & Slone, M. (2017). Community health workers improving diabetes outcomes in a rural Appalachian population. Social Work in Health Care, 56(2), 115-123. DOI: 10.1080/00981389.2016.1263269

Cao, M., Pu, T., Wang, L., Marshall, C., He, H., Hu, G., & Xiao, M. (2017). Early enriched physical environment reverses impairments of the hippocampus, but not medial prefrontal cortex, of socially-isolated mice. Brain, Behavior, and Immunity, 64, 232-243. DOI: 10.1016/j.bbi.2017.04.009

Kitzman, P., Hudson, K., Sylvia, V., Feltner, F., & Lovins, J. (2017). Care coordination for community transitions for individuals post-stroke returning to low-resource rural communities. Journal of Community Health, 42(3), 565-572. DOI: 10.1007/s10900-016-0289-0

Yin, M., Chen, Y., Zheng, H., Pu, T., Marshall, C., Wu, T., & Xiao, M. (2017). Assessment of mouse cognitive and anxiety-like behaviors and hippocampal inflammation following a repeated and intermittent paradoxical sleep deprivation procedure. Behavioural Brain Research, 321, 69-78. DOI: 10.1016/j.bbr.2016.12.034

Cardarelli, R., Roper, K. L., Cardarelli, K., Feltner, F. J., Prater, S., Ledford, K. M., Justice, B., Reese, D. R., Wagner, P., & Cantrell, C. (2017). Identifying community perspectives for a lung cancer screening awareness campaign in Appalachia Kentucky: The terminate lung cancer (TLC) study. Journal of Cancer Education, 32(1), 125-134. DOI: 10.1007/s13187-015-0914-0

Miller, J. J., Benner, K., Pope, N., Dumas, T., Damron, L. J., Segress, M., Slone, M., Thrasher, S., & Niu, C. (2017). Conceptualizing effective foster parent mentor programs: A participatory planning process. Children and Youth Services Review, 73, 411-418. DOI: 10.1016/j.childyouth.2017.01.004

Cardarelli, R., Reese, D., Roper, K. L., Cardarelli, K., Feltner, F. J., Studts, J. L., Knight, J. R., Armstrong, D., Weaver, A., & Shaffer, D. (2017). Terminate lung cancer (TLC) study—A mixed-methods population approach to increase lung cancer screening awareness and low-dose computed tomography in Eastern Kentucky. Cancer Epidemiology, 46, 1-8. DOI: 10.1016/j.canep.2016.11.003


Elliott, J. M., Dayanidhi, S., Hazle, C., Hoggarth, M. A., McPherson, J., Sparks, C. L., & Weber II, K. A. (2016). Advancements in imaging technology: Do they (or will they) equate to advancements in our knowledge of recovery in whiplash? Journal of Orthopaedic & Sports Physical Therapy, 46(10), 862-873. DOI: 10.2519/jospt.2016.6735

Huang, H., Nie, S., Cao, M., Marshall, C., Gao, J., Xiao, N., Hu, G., & Xiao, M. (2016). Characterization of AD-like phenotype in aged APPSwe/PS1dE9 mice. AGE, 38(4), 303-322. DOI: 10.1007/s11357-016-9929-7

Hazle Jr., C. R., & Lee, M. (2016). Strategies to overcome size and mechanical disadvantages in manual therapy. Journal of Manual & Manipulative Therapy, 24(3), 120-127. DOI: 10.1080/10669817.2015.1119371

Chen, Y. L., Wang, L. M., Chen, Y., Gao, J. Y., Marshall, C., Cai, Z. Y., Hu, G., & Xiao, M. (2016). Changes in astrocyte functional markers and β-amyloid metabolism-related proteins in the early stages of hypercholesterolemia. Neuroscience, 316, 178-191. DOI: 10.1016/j.neuroscience.2015.12.039

Xu, Z., Huang, H., Chen, Y., Gao, Y., Xu, J., Marshall, C., Cai, Z., & Xiao, M. (2016). Different expression patterns of amyloid- β protein precursor secretases in human and mouse hippocampal neurons: A potential contribution to species differences in neuronal susceptibility to amyloid- β pathogenesis. Journal of Alzheimer's Disease, 51(1), 179-195. DOI: 10.3233/JAD-150634


Xu, Z., Xiao, N., Chen, Y., Huang, H., Marshall, C., Gao, J., Cai, Z., Wu, T., Hu, G., & Xiao, M. (2015). Deletion of aquaporin-4 in APP/PS1 mice exacerbates brain Aβ accumulation and memory deficits. Molecular Neurodegeneration, 10(58). DOI: 10.1186/s13024-015-0056-1

Huang, H., Wang, L., Cao, M., Marshall, C., Gao, J., Xiao, N., Hu, G., & Xiao, M. (2015). Isolation housing exacerbates Alzheimer’s disease-like pathophysiology in aged APP/PS1 mice. International Journal of Neuropsychopharmacology, 18(7). DOI: 10.1093/ijnp/pyu116

Lee, M., & Hazle, C. (2015). Avascular necrosis of the femoral head. Journal of Orthopaedic & Sports Physical Therapy, 45(5), 425. DOI: 10.2519/jospt.2015.0405

Elam, C. L., Weaver, A. D., Whitler, E. T., Stratton, T. D., Asher, L. M., Scott, K. L., & Wilson, E. A. (2015). Discerning applicants’ interests in rural medicine: A textual analysis of admission essays. Medical Education Online, 20(1). DOI: 10.3402/meo.v20.27081


Yuan, C., Gao, J., Guo, J., Bai, L., Marshall, C., Cai, Z., Wang, L., & Xiao, M. (2014). Dimethyl sulfoxide damages mitochondrial integrity and membrane potential in cultured astrocytes. PLOS ONE. DOI: 10.1371/journal.pone.0107447

Hao, L., Huang, H., Gao, J., Marshall, C., Chen, Y., & Xiao, M. (2014). The influence of gender, age and treatment time on brain oxidative stress and memory impairment induced by D-galactose in mice. Neuroscience Letters, 571, 45-49. DOI: 10.1016/j.neulet.2014.04.038

Melton, C., Graff, C., Holmes, G., Brown, L., & Bailey, J. (2014). Health literacy and asthma management among African-American adults: An interpretative phenomenological analysis. Journal of Asthma, 51(7), 703-713. DOI: 10.3109/02770903.2014.906605

Snowden, J., Becker, J. A., Brosky, J. A., & Hazle, C. (2014). Chronic leg pain in a division II field hockey player: A case report. International Journal of Sports Physical Therapy, 9(1), 125-134.

Gu, M., Shen, L., Bai, L., Gao, J., Marshall, C., Wu, T., Ding, J., Miao, D., & Xiao, M. (2014). Heterozygous knockout of the Bmi-1 gene causes an early onset of phenotypes associated with brain aging. AGE, 36(1), 129-139. DOI: 10.1007/s11357-013-9552-9

Dignan, M., White, C., Schoenberg, N., Shelton, B., Feltner, F., Slone, S., Van Meter, E., DeSimone, C., & Ely, G. (2014). Effectiveness of an intervention for adherence to follow-up recommendations for abnormal pap tests in Appalachian Kentucky. Health Behavior and Policy Review, 1, 6-15. DOI: 10.14485/HBPR.1.1.2

Ely, G. E., White, C., Jones, K., Feltner, F., Gomez, M., Shelton, B., Slone, S., Van Meter, E., DeSimone, C., Schoenberg, N., & Dignan, M. (2014). Cervical cancer screening:  Exploring Appalachian patients’ barriers to follow-up care. Social Work in Health Care, 53(2), 83-95. DOI: 10.1080/00981389.2013.827149


Liu, X., Lu, Y., Gao, J., Marshall, C., Xiao, M., Miao, D., Karaplis, A., Goltzman, D., & Ding J. (2013). Calcium sensing receptor absence delays postnatal brain development via direct and indirect mechanisms. Molecular Neurobiology, 48(3), 590-600. DOI: 10.1007/s12035-013-8448-0

Xu, Z., Zhang, L., Wang, Q., Marshall, C., Xiao, N., Gao, J., Wu, T., Ding, J., Hu, G., & Xiao, M. (2013). Aerobic exercise combined with antioxidative treatment does not counteract moderate- or mid-stage Alzheimer-like pathophysiology of APP/PS1 mice. CNS Neuroscience & Therapeutics, 19(10), 795-803. DOI: 10.1111/cns.12139 

Malone, T., & Hazle, C. (2013). Diagnostic imaging of the throwing athlete’s shoulder. International Journal of Sports Physical Therapy, 8(5), 641-651.


Hazle, C., & Duby, C. (2012). Anterior cruciate ligament injury diagnosis and management in a pediatric patient: A case report. International Journal of Sports Physical Therapy, 7(6), 678-690.

Faulkner, A. L., Wilson, E. A., Whitler, E. T., & Asher, L. M. (2012). Role of international medical graduates in Kentucky medicine: Implications for workforce planning and medical education. Center for Excellence in Rural Health Faculty Publications. 3.

Donaldson, E. A., Holtgrave, D. R., Duffin, R. A., Feltner, F., Funderburk, W., & Freeman, H. P. (2012). Patient navigation for breast and colorectal cancer in 3 community hospital settings. Cancer, 118(19), 4851-4859. DOI: 10.1002/cncr.27487

Gao, J., Tan, M., Gu, M., Marshall, C., Ding, J., Hu, G., & Xiao, M. (2012). Cellular localization of aquaporin-1 in the human and mouse trigeminal systems. PLOS ONE, 7(9) DOI: 10.1371/journal.pone.0046379

O’Grady, W., & Hazle, C. (2012). Persistent wrist pain in a mature golfer. International Journal of Sports Physical Therapy, 7(4), 425-432.

Gross, D. A., Bates, P., Knox, T. L., & Gayheart, M. W. (2012). Mining for future health care providers in Appalachian Kentucky. Journal of Health Care for the Poor and Underserved, 23(2), 694-704. DOI: 10.1353/hpu.2012.0068

Feltner, F. J., Ely, G. E., Whitler, E. T., Gross, D., & Dignan, D. (2012). Effectiveness of community health workers in providing outreach and education for colorectal screening in Appalachian Kentucky. Social Work in Health Care, 51(5), 430-440. DOI: 10.1080/00981389.2012.657296

Cao, G., Gu, M., Zhu, M., Gao, J., Yin, Y., Marshall, C., Xiao, M., Ding, J., & Miao. D. (2012). Bmi-1 absence causes premature brain degeneration. PLOS ONE, 7(2). DOI: 10.1371/journal.pone.0032015

Liu, L., Lu, Y., Kong, H., Liu, L., Marshall, C., Xiao, M., Ding, J., Gao, J., & Hu, G. (2012). Aquaporin-4 deficiency exacerbates brain oxidative damage and memory deficits induced by long-term ovarian hormone deprivation and D-galactose injection. International Journal of Neuropsychopharmacology, 15(1), 55-68. DOI: 10.1017/S1461145711000022

Hazle, C. R., & Nitz, A. J. (2012). A simulated passive intervertebral motion task: Observations of performance in a cross-sectional study. Journal of Manual & Manipulative Therapy, 20(3), 121-129. DOI: 10.1179/2042618612Y.0000000004


Wilson, E. A., Whitler, E. T., & Asher, L. M. (2011). Meeting the need of a rural state for primary care physicians: A health care reform challenge. Journal of Public Health Management and Practice, 17(2), 147-153. DOI: 10.1097/PHH.0b013e3181e1656d

Li, L., Ding, J., Marshall, C., Gao, J., Hu, G., & Xiao, M. (2011). Pretraining affects Morris water maze performance with different patterns between control and ovariectomized plus D-Galactose-injected mice. Behavioural Brain Research, 217(1), 244-247. DOI: 10.1016/j.bbr.2010.10.032

Hazle, C. R. (2011). Case report of atypical bilateral posteromedial knee instability in a male recreational runner. Physiotherapy Theory and Practice, 27(2), 160-171. DOI: 10.3109/09593981003796497


Gross, D. A. (2010). The relationship between educational attainment and lung cancer mortality in Kentucky: Implications for nurses. Online Journal of Rural Nursing and Health Care, 10(2).

Xiao, M., Cao, G., Marshall, C., & Hu, G. (2010). Hypothesis: Multiple factors are associated with the lack of any beneficial effects of oestrogen-replacement therapy in the late postmenopausal stage. Clinical and Experimental Pharmacology and Physiology, 37(8), 873-876. DOI: 10.1111/j.1440-1681.2010.05400.x

York, N. L., Rayens, M. K., Zhang, M., Jones, L. G., Casey, B. R., & Hahn, E. J. (2010). Strength of tobacco control in rural communities. The Journal of Rural Health, 26(2), 120-128. DOI: 10.1111/j.1748-0361.2010.00273.x

Lu, N., Samuels, M. E., Kletke, P. R., & Whitler, E. T. (2010). Rural-urban differences in health insurance coverage and patterns among working-age adults in Kentucky. The Journal of Rural Health, 26(2), 129-138. DOI: 10.1111/j.1748-0361.2010.00274.x


Anderson, D. M., Whitler, E. T., Johnson, A. O., Elam, C. L., Wilson, E. A., & Asher, L. M. (2009). Increasing the medical school applicant pool:  A key to training more rural physicians. Journal of the Kentucky Medical Association, 107, 355-360.

Methvin, J. N., Mannino, D. M., & Casey, B. R. (2009). COPD prevalence in southeastern Kentucky: The burden of lung disease study. Chest, 135(1), 102-107. DOI: 10.1378/chest.08-1315


Anderson, D., Asher, L. M., Whitler, E., & Wilson, E. A. (2008). The impact of health on Kentucky’s economy. Journal of the Kentucky Medical Association, 106, 321-328.

Gross, D. A., Bowling, B., Bates, W., Clemons, K., & Casey, B. R. (2008). Southeastern Ky. physician assistant needs assessment. Paper for the University of Kentucky Center of Excellence in Rural Health.

Gross, D. A., & Feltner, F. (2008). House calls-21st century style: A home health technology project in rural Kentucky. Rural Roads, 6(1), 8-9, 11.

Hazle, C. R., & Nitz, A. J. (2008). Evidence-based assessment and diagnosis of pelvic girdle disorders: A proposal for an alternate diagnostic category. Physical Therapy Reviews, 13(1), 25-36. DOI: 10.1179/174328808X251975


Owens, J., Gross, D. A., & Lewis, P. (2005). Nurse anesthetists in southeastern Kentucky: A survey of supply versus demand. Center for Excellence in Rural Health Reports. 2.

Whitler, E. T., Feltner, F., Owens, J., & Gross, D. A. (2005). Kentucky Homeplace defeat diabetes screening test: An analysis of rural Kentucky’s challenge to overcome the growing diabetes epidemic. Journal of the Kentucky Medical Association, 103, 307-314.


Casey, B. R., Jones, J., Gross, D. A., & Dixon, L. (2004). Rural Kentucky's physician shortage: Strategies for producing, recruiting and retaining primary care providers within a medically underserved region. Center for Excellence in Rural Health Reports. 1.


Feltner, F., & Whitler, E. (2002). Diabetes: Half the state at risk; Preventable with diet and exercise. Rural Health Update.