Deletion of Aquaporin-4 in APP/PS1 Mice Exacerbates Brain Aβ Accumulation and Memory Deficits
Preventing or reducing amyloid-beta (Aβ) accumulation in the brain is an important therapeutic strategy for Alzheimer’s disease (AD). Recent studies showed that the water channel aquaporin-4 (AQP4) mediates soluble Aβ clearance from the brain parenchyma along the paravascular pathway. However, the direct evidence for roles of AQP4 in the pathophysiology of AD remains absent. The article was published in the November 2015 issue of the journal Molecular Neurodegeneration.

Appalachian Research Day: Come Sit on the Porch
Appalachian Research Day is a one-day annual event that offers a unique forum for university-based researchers to disseminate health disparities research findings directly into the community where the research was conducted. Research participants, healthcare providers and community stakeholders attend the event to learn the outcomes of community-based studies focused on diabetes, stroke, heart disease and cancer.  The poster was presented at the Appalachian Translational Research Network Health Summit, October 15-16, 2015, in Charleston, WV.

Bridges to Home Navigating High-Risk Inpatient Clients Using a Lay-Health Worker Model in Eastern Kentucky
Roughly 20% of all Medicare fee-for-service clients are readmitted within 30 days of hospital discharge, resulting in $17 billion annually. It is estimated that 75% of these readmissions are avoidable. Research has demonstrated that a broad range of socioeconomic and personal factors impact readmission rates. This study seeks to address such factors through a hospital-based Lay Health Worker (LHW) model for transition of care. The poster was presented at the Appalachian Translational Research Network Health Summit, October 15-16, 2015, in Charleston, WV.

Care Coordination as Part of the Discharge Plan to Support Community Reintegration of Individuals with Stroke Living in Appalachian Rural Communities
The purpose of this study was to determine the effectiveness of providing community health navigation to facilitate continued communications with healthcare providers and linkages to services and community resources for survivors of stroke in Appalachian rural communities. The poster was presented at the Appalachian Translational Research Network Health Summit, October 15-16, 2015, in Charleston, WV.

Identifying Community Perspectives for a Lung Cancer Screening Awareness Campaign in Appalachia Kentucky: The Terminate Lung Cancer (TLC) Study
Lung cancer screening with low-dose computed tomography (LDCT) scan is now covered by Centers for Medicare & Medicaid Services following an evidence-based recommendation, but a shared decision making process should inform patients of risks and limitations. An awareness campaign promoting LDCT screenings is an opportunity to elicit patient engagement with health providers about the risks and benefits. Focus groups representing three regions of Appalachian Kentucky known for high lung cancer rates discussed development of a lung cancer screening campaign. Recommendations included messaging content, appeals or design, campaign implementation, and trusted information or communication sources. Community health workers (CHWs) from three Eastern Kentucky regions recruited individuals from their local communities using established client files. This article was published online, September 28, 2015, in the Journal of Cancer Education.

Discerning Applicants’ Interests in Rural Medicine: A Textual Analysis of Admission Essays
Despite efforts to construct targeted medical school admission processes using applicant-level correlates of future practice location, accurately gauging applicants’ interests in rural medicine remains an imperfect science. This study explores the usefulness of textual analysis to identify rural-oriented themes and values underlying applicants’ open-ended responses to admission essays. The article was published in the March 19, 2015 issue of the journal Medical Education Online.

Isolation Housing Exacerbates Alzheimer’s Disease-Like Pathophysiology in Aged APP/PS1 Mice
Alzheimer’s disease is a neurodegenerative disease characterized by gradual declines in social, cognitive, and emotional functions, leading to a loss of expected social behavior. Social isolation has been shown to have adverse effects on individual development and growth as well as health and aging. Previous experiments have shown that social isolation causes an early onset of Alzheimer’s disease-like phenotypes in young APP695/PS1-dE9 transgenic mice. However, the interactions between social isolation and Alzheimer’s disease still remain unknown. The article was published in the January 2015 issue of the International Journal of Neuropsychopharmacology.